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Home - Products - Antibody Drug Conjugates (ADC) - ADCs Linker/Click Chemistry - 6-Maleimidohexanoic acid N-hydroxysuccinimide ester

6-Maleimidohexanoic acid N-hydroxysuccinimide ester

CAS No. 55750-63-5

6-Maleimidohexanoic acid N-hydroxysuccinimide ester( EMCS )

Catalog No. M15025 CAS No. 55750-63-5

A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity; a useful protective group in antibody drug conjugates.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester
  • Note
    Research use only, not for human use.
  • Brief Description
    A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity; a useful protective group in antibody drug conjugates.
  • Description
    A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity; a useful protective group in antibody drug conjugates.
  • In Vitro
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester is coupled to the peptides, and then conjugated to the Adenovirus vector containing luciferase gene as adenovirus vector carrier.
  • In Vivo
    ——
  • Synonyms
    EMCS
  • Pathway
    Antibody Drug Conjugates (ADC)
  • Target
    ADCs Linker/Click Chemistry
  • Recptor
    ADCs Linker/Click Chemistry
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    55750-63-5
  • Formula Weight
    308.2867
  • Molecular Formula
    C14H16N2O6
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1CC(=O)N(C1=O)OC(=O)CCCCCN2C(=O)C=CC2=O
  • Chemical Name
    1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ehrlich GK, et al. Bioconjug Chem. 2013 Dec 18;24(12):2015-24. 2. Maeda M, et al. Bioorg Med Chem Lett. 2005 Feb 1;15(3):621-4. 3. Kida S, et al. Bioorg Med Chem Lett. 2006 Feb;16(3):743-5.
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